Understanding how mutations in the ASXL1 gene affect blood cell development and cancer risk.
Molecular and Cellular Mechanisms of Mutant ASXL1-driven Clonal Hematopoiesis
This study is looking at a condition called clonal hematopoiesis of indeterminate potential (CHIP), which happens when certain blood cells with mutations grow more than they should, especially in older adults, and it aims to understand how this can increase the risk of blood cancers and other health issues, with the hope of finding new treatments or ways to prevent these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10881106 on NIH RePORTER |
What this research studies
This research investigates clonal hematopoiesis of indeterminate potential (CHIP), a condition where blood cells with mutations expand, particularly focusing on the ASXL1 gene. The study examines how these mutations, which are more common in older adults, lead to an increased risk of blood cancers and other diseases. By analyzing the bone marrow environment and the effects of specific treatments on mutated cells, the research aims to uncover the underlying mechanisms and potential therapeutic targets. Patients may benefit from insights that could lead to new treatments or preventive strategies for blood-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults with clonal hematopoiesis or mutations in the ASXL1 gene.
Not a fit: Patients without mutations in the ASXL1 gene or those who are younger and do not exhibit clonal hematopoiesis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients at risk of blood cancers due to genetic mutations.
How similar studies have performed: Previous research has shown promising results in understanding clonal hematopoiesis and its implications for blood cancers, suggesting that this approach has potential for success.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Zhang, Jing — University of Wisconsin-Madison
- Study coordinator: Zhang, Jing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.