Understanding how mutations in the ARID1B gene affect brain development in children with neurodevelopmental disorders.
Official title: Revealing the Defects in Gene Regulation that Link ARID1B to a Spectrum of Neurodevelopmental Disorders
Funded at Emory University · NIH-11090323 · Data updated 2026-11-12
This study is looking at how changes in the ARID1B gene might affect brain development in children with neurodevelopmental disorders, helping us understand their challenges better and find ways to support them.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | May 2, 2024 |
| Project end | May 1, 2027 |
| Funding year | 2025 |
| Award (this year) | $49,538 |
| NIH project number | 5F31HD112113-02 |
| Project ID | NIH-11090323 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are diagnosed with neurodevelopmental disorders, particularly those with suspected ARID1B mutations.
✕Less likely to help
Patients who do not have neurodevelopmental disorders or those whose conditions are unrelated to genetic mutations in ARID1B may not benefit from this research.
What this research studies
This research investigates the role of the ARID1B gene in neurodevelopmental disorders (NDD) that affect children. It focuses on how both coding and non-coding mutations in this gene influence brain development and contribute to various cognitive, social, and behavioral challenges. By analyzing these mutations, the research aims to identify specific gene regulatory networks that are disrupted in affected children, which could lead to better understanding and potential interventions. The approach includes genomic studies and bioinformatics to pinpoint critical areas in the genome that may be responsible for these disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for children with neurodevelopmental disorders linked to ARID1B mutations.
How similar studies have gone: Previous research has shown promising results in understanding the genetic basis of neurodevelopmental disorders, indicating that this approach could yield valuable insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Loskove, Yonina — Emory University
- Study coordinator: Loskove, Yonina
Related research
Other NIH-funded projects on the same topics.
-
Intergenerational factors in neurodevelopmental disorders
This project looks at how experiences before and during pregnancy across generations may influence the risk of neurodevelopmental conditions like ADHD, autism, and related disorders in grandchildren.
-
Understanding brain signals in autism to identify biologically distinct subtypes
This study uses EEG to link how the brain processes sensory information with behavior in young children with autism and related concerns.
-
Clinical Translational Research Center for Neurodevelopmental Disorders
A funded center supports research on neurodevelopmental disorders like Angelman syndrome and autism to better understand causes and improve treatments for children.
-
Synaptic nanostructure in neurodevelopmental disorders
This project aims to map the tiny architecture of brain synapses in native cells to understand how connections form and change in neurodevelopmental disorders.
-
Maternal acetaminophen use in pregnancy and ADHD risk in children
A large study will follow thousands of mother-child pairs to see if taking acetaminophen during pregnancy relates to ADHD in kids.
-
GDF11’s role in brain development and autism-related disorders
A new NIH grant tests whether adjusting a growth factor called GDF11 can improve brain function and behaviors in models related to autism and other neurodevelopmental disorders.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.