Understanding how mutations in the ARID1B gene affect brain development in children with neurodevelopmental disorders.
Revealing the Defects in Gene Regulation that Link ARID1B to a Spectrum of Neurodevelopmental Disorders
['FUNDING_FELLOWSHIP'] · EMORY UNIVERSITY · NIH-11090323
This study is looking at how changes in the ARID1B gene might affect brain development in children with neurodevelopmental disorders, helping us understand their challenges better and find ways to support them.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11090323 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the ARID1B gene in neurodevelopmental disorders (NDD) that affect children. It focuses on how both coding and non-coding mutations in this gene influence brain development and contribute to various cognitive, social, and behavioral challenges. By analyzing these mutations, the research aims to identify specific gene regulatory networks that are disrupted in affected children, which could lead to better understanding and potential interventions. The approach includes genomic studies and bioinformatics to pinpoint critical areas in the genome that may be responsible for these disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are diagnosed with neurodevelopmental disorders, particularly those with suspected ARID1B mutations.
Not a fit: Patients who do not have neurodevelopmental disorders or those whose conditions are unrelated to genetic mutations in ARID1B may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for children with neurodevelopmental disorders linked to ARID1B mutations.
How similar studies have performed: Previous research has shown promising results in understanding the genetic basis of neurodevelopmental disorders, indicating that this approach could yield valuable insights.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LOSKOVE, YONINA — EMORY UNIVERSITY
- Study coordinator: LOSKOVE, YONINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder, Autistic Disorder, autistic spectrum disorder