Understanding how mutations in PCNA lead to cancer
Mechanism of Disease-causing mutations in PCNA
This study is looking at how certain changes in a protein called PCNA, which helps with DNA repair, might lead to a higher risk of cancer for people with those changes, so we can better understand how DNA repair problems happen.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10699962 on NIH RePORTER |
What this research studies
This research investigates the role of PCNA, a protein essential for DNA processes, in the development of cancer due to specific mutations. By examining how these mutations affect PCNA's stability and its ability to interact with other proteins, the study aims to uncover the mechanisms behind DNA repair disorders. Patients with mutations in PCNA may have impaired DNA repair, leading to increased cancer risk. The research employs biochemical assays and cellular models to analyze the effects of these mutations on PCNA function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with known mutations in the PCNA gene or those diagnosed with PCNA Associated DNA Repair Disorder (PARD).
Not a fit: Patients without mutations in the PCNA gene or those not affected by DNA repair disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting PCNA to improve cancer treatment.
How similar studies have performed: Previous research has shown that targeting DNA repair mechanisms can be effective in treating certain cancers, suggesting potential success for this approach.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Kelch, Brian Anthony — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Kelch, Brian Anthony
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.