Understanding how mutations in Myosin Vb affect nutrient absorption in children
Impacting the pathophysiology of malabsorption induced by Myosin Vb inactivating mutations
This study is looking at how a protein called Myosin Vb affects nutrient absorption in kids with a condition called microvillus inclusion disease, and it aims to find new ways to help improve their symptoms by testing new treatments that could help their intestines work better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10896167 on NIH RePORTER |
What this research studies
This research investigates the role of Myosin Vb, a protein essential for nutrient absorption in the intestines, particularly in children with congenital diarrheal disease known as microvillus inclusion disease (MVID). The study explores how mutations in this protein lead to malabsorption and severe diarrhea. By testing new compounds that activate specific receptors, the research aims to improve the localization of important proteins that help absorb nutrients and water in the intestines. The approach includes using animal models and potentially translating findings to human patients to enhance treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old diagnosed with microvillus inclusion disease or related malabsorption conditions.
Not a fit: Patients with malabsorption issues not related to Myosin Vb mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for children suffering from malabsorption due to Myosin Vb mutations, potentially reducing life-threatening diarrhea and improving their nutritional status.
How similar studies have performed: Other research has shown promise in using receptor agonists to improve intestinal function, suggesting that this approach may yield beneficial results.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Kaji, Izumi — Vanderbilt University Medical Center
- Study coordinator: Kaji, Izumi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.