Understanding how mutations in mitochondrial DNA affect cell function
Mechanisms of mutant mitochondrial genome modulation
This study is looking at how changes in the tiny energy-producing parts of our cells, called mitochondria, can affect our health, using a small worm as a model, to help us learn more about mitochondrial diseases and find new ways to treat them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11009951 on NIH RePORTER |
What this research studies
This research investigates the genetic mechanisms of mitochondrial DNA (mtDNA) and how mutations in this DNA can influence cellular functions. By using the model organism C. elegans, the study aims to explore the replication and mutation processes of mtDNA, which can lead to various cellular conditions. The research will involve genetic manipulation techniques to better understand the implications of mtDNA mutations on health and disease. Patients may benefit from insights gained about mitochondrial diseases and potential therapeutic approaches.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with known mitochondrial disorders or those at risk for such conditions.
Not a fit: Patients with conditions unrelated to mitochondrial function or those without genetic predispositions to mitochondrial diseases may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating diseases caused by mitochondrial DNA mutations.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial genetics, indicating that this approach has potential for significant advancements in the field.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Patel, Maulik R — Vanderbilt University
- Study coordinator: Patel, Maulik R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.