Understanding how mutations in microbes affect their evolution and drug resistance
Official title: Empirical and Theoretical Studies of Adaptive Mutations in Microbes and Their Evolutionary Consequences
Funded at University of California, San Diego · NIH-11055367 · Data updated 2026-11-12
This study looks at how changes in tiny germs like bacteria and yeast help them survive and resist antibiotics, with the goal of finding ways to better fight drug-resistant infections that can affect patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | March 13, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $348,522 |
| NIH project number | 5R35GM153242-02 |
| Project ID | NIH-11055367 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals with infections caused by antibiotic-resistant bacteria.
✕Less likely to help
Patients with non-infectious conditions or those not affected by antibiotic resistance may not receive any benefit from this research.
What this research studies
This research investigates how mutations in microbes, such as bacteria and yeast, influence their ability to survive and adapt, particularly in the context of antibiotic resistance. The project combines theoretical modeling with experimental studies to predict how these mutations affect microbial fitness across different environments. By analyzing the genetic changes in organisms like E. coli and Baker's yeast, the researchers aim to uncover patterns that could inform strategies to combat drug-resistant infections. Patients may benefit from insights gained about microbial evolution and resistance mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating antibiotic-resistant infections.
How similar studies have gone: Previous research has shown success in understanding microbial evolution and drug resistance, making this approach both relevant and promising.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Kryazhimskiy, Sergey a. — University of California, San Diego
- Study coordinator: Kryazhimskiy, Sergey a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.