Understanding how mutations in lamin A/C affect heart rhythm disorders
Official title: Mechanisms of Lamin A/C-mediated Cardiac Conduction Disorders
Funded at Baylor College of Medicine · NIH-10802802 · Data updated 2026-11-12
This study is looking at how certain genetic changes in a protein called lamin A/C can cause heart rhythm problems, and it's for people who have these issues; by using specially modified mice, researchers hope to find new ways to help treat these conditions beyond just using pacemakers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 25, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $704,071 |
| NIH project number | 1R01HL166832-01A1 |
| Project ID | NIH-10802802 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with known lamin A/C mutations or those diagnosed with cardiac conduction disorders such as atrioventricular block or sick sinus syndrome.
✕Less likely to help
Patients without any genetic predisposition to cardiac conduction disorders or those with other unrelated heart conditions may not benefit from this research.
What this research studies
This research investigates the role of lamin A/C mutations in causing cardiac conduction disorders (CCDs), which disrupt the heart's electrical impulses and lead to arrhythmias. By studying genetically modified mice that carry a specific mutation, researchers aim to uncover the molecular mechanisms that link these mutations to heart rhythm problems. The findings could pave the way for new treatments beyond the current reliance on pacemakers for patients with these conditions. The research employs advanced techniques like ATAC sequencing to analyze changes in gene expression related to heart function.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for patients suffering from cardiac conduction disorders, potentially reducing the need for pacemaker implantation.
How similar studies have gone: Previous studies have shown promising results in understanding genetic contributions to cardiac disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Chelu, Mihail Gabriel — Baylor College of Medicine
- Study coordinator: Chelu, Mihail Gabriel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.