Understanding how mutations in histone genes affect cancer growth using yeast models
Official title: Leveraging a budding yeast model to characterize the functional consequences of mutations in histone genes that are implicated in human disease
Funded at Emory University · NIH-11019691 · Data updated 2026-11-12
This study is looking at how certain gene changes can lead to cancer by using yeast, which is similar to human genetics, and it aims to find out how these changes react to cancer treatments to help discover new ways to fight the disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $75,520 |
| NIH project number | 5F32GM153152-02 |
| Project ID | NIH-11019691 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers linked to histone gene mutations.
✕Less likely to help
Patients with cancers not associated with histone mutations may not benefit from this research.
What this research studies
This research investigates the role of histone gene mutations in cancer development by using a model organism, budding yeast, which shares significant genetic similarities with humans. The study focuses on specific mutations, such as H3K36M, that disrupt normal gene expression and DNA structure, leading to diseases like cancer. By examining how these mutations respond to various anti-cancer drugs, researchers aim to uncover the underlying mechanisms of cancer growth and identify potential therapeutic targets. The approach includes high-throughput screening to find proteins that can mitigate the effects of these mutations.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers associated with histone mutations.
How similar studies have gone: Previous research using similar yeast models has successfully identified key mechanisms of cancer growth, suggesting this approach has potential for meaningful insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Jones, Celina Yvonne — Emory University
- Study coordinator: Jones, Celina Yvonne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.