Understanding how mutations in histone genes affect cancer growth using yeast models
Leveraging a budding yeast model to characterize the functional consequences of mutations in histone genes that are implicated in human disease
['FUNDING_FELLOWSHIP'] · EMORY UNIVERSITY · NIH-11019691
This study is looking at how certain gene changes can lead to cancer by using yeast, which is similar to human genetics, and it aims to find out how these changes react to cancer treatments to help discover new ways to fight the disease.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11019691 on ClinicalTrials.gov |
What this research studies
This research investigates the role of histone gene mutations in cancer development by using a model organism, budding yeast, which shares significant genetic similarities with humans. The study focuses on specific mutations, such as H3K36M, that disrupt normal gene expression and DNA structure, leading to diseases like cancer. By examining how these mutations respond to various anti-cancer drugs, researchers aim to uncover the underlying mechanisms of cancer growth and identify potential therapeutic targets. The approach includes high-throughput screening to find proteins that can mitigate the effects of these mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers linked to histone gene mutations.
Not a fit: Patients with cancers not associated with histone mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers associated with histone mutations.
How similar studies have performed: Previous research using similar yeast models has successfully identified key mechanisms of cancer growth, suggesting this approach has potential for meaningful insights.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JONES, CELINA YVONNE — EMORY UNIVERSITY
- Study coordinator: JONES, CELINA YVONNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents, anti-cancer drug