Understanding how mutations in healthy cells relate to aging
Somatic mutation rates in healthy aging
This study is looking at how tiny changes in our healthy cells might build up over time and affect how we age, using blood samples from many people to see if these changes are linked to health and aging-related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11080366 on NIH RePORTER |
What this research studies
This research investigates the accumulation of somatic mutations in healthy cells over time and their potential role in the aging process. By utilizing advanced sequencing technologies, the study aims to measure mutation rates in blood samples from large cohorts, including data on individual health, lifestyle, and environmental factors. The goal is to uncover how these mutation rates vary among individuals and their possible links to aging-related diseases and mortality. This comprehensive approach could provide new insights into the biological mechanisms of aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are healthy individuals of various ages who are willing to provide blood samples and health information.
Not a fit: Patients with existing serious health conditions or those who are not willing to participate in blood sampling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new strategies for preventing or treating aging-related diseases.
How similar studies have performed: While the approach of measuring somatic mutation rates in large populations is relatively novel, similar studies have shown promising results in understanding genetic contributions to aging.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Shoag, Jonathan — Case Western Reserve University
- Study coordinator: Shoag, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.