Understanding how mutations in genomes affect cell function and disease susceptibility
The evolution and diversity of mutation, molecular fidelity, and genome structure
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-11025606
This study is looking at how changes in our genes over time can affect how our cells work and how likely we are to get diseases, especially cancer, so we can better understand why some cells are more at risk than others.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-11025606 on ClinicalTrials.gov |
What this research studies
This research investigates the emergence and impact of mutations in genomes over time, focusing on how these changes can influence cell function and disease susceptibility. By examining both normal and cancerous cells, the study aims to uncover the mechanisms that lead to genetic diversity and how specific cell types may be more prone to diseases. The researchers will utilize advanced genomic methodologies to identify and analyze somatic mutations, which are changes that occur in individual cells throughout an organism's life. This work could provide insights into the evolutionary processes that shape genomes and contribute to health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of genetic disorders or those diagnosed with cancers that may have a genetic component.
Not a fit: Patients with stable, non-genetic conditions or those without a significant family history of genetic diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic factors that influence disease susceptibility, potentially informing new treatment strategies.
How similar studies have performed: Previous research has shown success in understanding somatic mutations in cancer, but this approach to studying normal cells is relatively novel.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUDMANT, PETER HESHEDAHL — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: SUDMANT, PETER HESHEDAHL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers