Understanding how mutations in genomes affect cell function and disease susceptibility
The evolution and diversity of mutation, molecular fidelity, and genome structure
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-10866523
This study is looking at how changes in our genes can affect how our cells work and why some people might get sick more easily, especially by focusing on normal cells instead of just cancer cells, to help us understand the differences between cell types and their genetic backgrounds.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-10866523 on ClinicalTrials.gov |
What this research studies
This research investigates the emergence and impact of mutations in genomes, focusing on how these changes influence cell function and disease susceptibility. By examining both cellular and organismal levels, the study aims to uncover the relationship between cell type, genotype, and evolutionary history on genome structure. The researchers will utilize advanced genomic methodologies to identify somatic mutations in normal cells, which are often overlooked compared to those in cancer cells. This work could provide insights into why certain cell types are more prone to diseases and how genetic diversity contributes to phenotypic variation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of genetic disorders or those interested in understanding their genetic predispositions to diseases.
Not a fit: Patients with no genetic predisposition to diseases or those not interested in genetic research may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of disease mechanisms and potential new strategies for prevention and treatment.
How similar studies have performed: Previous research has shown success in understanding somatic mutations in cancer, but this approach to studying normal cells is relatively novel.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUDMANT, PETER HESHEDAHL — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: SUDMANT, PETER HESHEDAHL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers