Understanding how mutations in calmodulin affect heart rhythms
Official title: Multi-scale computational modeling of calmodulin mutations associated with CPVT
Funded at California State University Northridge · NIH-11078834 · Data updated 2026-11-12
This study is looking at how certain genetic changes in a protein called calmodulin affect heart rhythms in people with a serious heart condition called CPVT, using computer models to better understand these changes and find ways to improve treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State University Northridge NIH-funded |
| Lab location | 1 site (Northridge, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $147,500 |
| NIH project number | 5R16GM153647-02 |
| Project ID | NIH-11078834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Catecholaminergic Polymorphic Ventricular Tachycardia or those with a family history of this condition.
✕Less likely to help
Patients with arrhythmias not linked to calmodulin mutations or those without a genetic predisposition to CPVT may not benefit from this research.
What this research studies
This research investigates the genetic mutations in calmodulin that are linked to a serious heart condition called Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT). By using advanced computer modeling techniques, the researchers aim to simulate how these mutations impact calcium signaling in heart cells, which is crucial for maintaining normal heart rhythms. The study will involve detailed molecular dynamics simulations to understand the interactions between calmodulin and a key protein involved in calcium release, and then connect these findings to how they affect heart tissue's electrical activity. This approach could help clarify the mechanisms behind arrhythmias and lead to better treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with CPVT and related arrhythmias.
How similar studies have gone: While the approach of using multi-scale computational modeling is innovative, similar studies have shown promise in understanding genetic influences on cardiac function.
Where this research is happening
-
California State University Northridge
Northridge, United States Active
Researchers
- Principal investigator: Shiferaw, Yohannes — California State University Northridge
- Study coordinator: Shiferaw, Yohannes
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.