Understanding how mutations in adult brains increase with age
Uncovering the origin of hypermutability in adult brains
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-10987022
This study is looking at how genetic changes in the brains of adults over 40 might increase as we age, which could help us understand more about age-related brain diseases and cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10987022 on ClinicalTrials.gov |
What this research studies
This research investigates the phenomenon of hypermutability in the brains of adults, particularly focusing on how genetic mutations accumulate as individuals age. By examining brain samples from adults over 40, the study aims to determine the origins and implications of these mutations, which may contribute to age-related neurodegenerative diseases and potentially brain cancer. The researchers will expand their sample size and analyze the distribution of mutations across different brain regions to gain insights into this process.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 40 and older, particularly those with concerns about neurodegenerative diseases or cognitive decline.
Not a fit: Patients under 40 years old or those without any neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential interventions for age-related neurodegenerative diseases and brain cancer.
How similar studies have performed: Previous research has indicated that genetic mutations play a significant role in neurodegenerative diseases, suggesting that this study's approach could yield valuable insights.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ABYZOV, ALEXEJ — MAYO CLINIC ROCHESTER
- Study coordinator: ABYZOV, ALEXEJ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder, age associated neurodegenerative disease, age associated neurodegenerative disorder, age dependent disease