Understanding how mutations in a specific protein lead to a type of cerebellar ataxia.
Structural and Molecular Mechanisms for Dysregulation of Protein Kinase C Gamma in Cerebellar Ataxia
This study is looking at how changes in a specific protein, called PKCg, might cause Spinocerebellar Ataxia 14 (SCA14), a condition that affects movement, and aims to find out how these changes impact brain cells important for coordination, which could help in developing new treatments for people with SCA14.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11032823 on NIH RePORTER |
What this research studies
This research investigates the role of protein kinase C gamma (PKCg) mutations in causing Spinocerebellar Ataxia 14 (SCA14), a neurodegenerative disease. The team will explore how these mutations affect the structure and function of PKCg, particularly in Purkinje cells of the cerebellum, which are crucial for motor coordination. By utilizing advanced techniques in structural biology and computational modeling, the research aims to uncover the mechanisms by which these mutations lead to neuronal degeneration. This understanding could pave the way for new therapeutic strategies targeting the underlying causes of SCA14.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Spinocerebellar Ataxia 14 or those with genetic mutations linked to this condition.
Not a fit: Patients with other forms of ataxia not related to PKCg mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Spinocerebellar Ataxia 14.
How similar studies have performed: Previous research has shown promising results in understanding similar neurodegenerative mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Newton, Alexandra C. — University of California, San Diego
- Study coordinator: Newton, Alexandra C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.