Understanding how mutations in a specific gene lead to cancer
Mechanisms of Genome Instability in Tumors with DNA Polymerase Epsilon Mutations
This study is looking at how changes in the POLE gene might cause certain types of colorectal and endometrial cancers to become more unstable and risky, with the hope that understanding these changes can help improve treatments for patients with these cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10752621 on NIH RePORTER |
What this research studies
This research investigates the role of mutations in the POLE gene, which is linked to colorectal and endometrial cancers that exhibit high levels of genetic mutations. The study aims to uncover the mechanisms by which these mutations contribute to genomic instability and cancer risk. By examining how these mutations affect DNA replication and the function of other cellular mechanisms, the research seeks to provide insights that could lead to better understanding and treatment of these cancers. Patients with these specific cancer types may benefit from the findings as they could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colorectal or endometrial cancers that have been identified to have POLE gene mutations.
Not a fit: Patients without colorectal or endometrial cancers, or those whose cancers are not associated with POLE mutations, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with colorectal and endometrial cancers associated with POLE mutations.
How similar studies have performed: While the specific mechanisms being investigated are novel, previous research has shown that understanding genetic mutations can lead to significant advancements in cancer treatment.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Shcherbakova, Polina V — University of Nebraska Medical Center
- Study coordinator: Shcherbakova, Polina V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.