Understanding how mutant STAT6 affects follicular lymphoma
The Biology of Mutant STAT6 in Follicular Lymphoma
This study is looking at how certain changes in a gene called STAT6 affect follicular lymphoma, a type of cancer, to help find better treatments that work for patients based on their unique genetic makeup.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10896187 on NIH RePORTER |
What this research studies
This research investigates the role of mutant STAT6 in follicular lymphoma, a common type of non-Hodgkin's lymphoma. The team aims to identify how these mutations contribute to the disease's progression and resistance to current therapies. By analyzing genetic changes and their effects on B cell survival, the research seeks to uncover potential new targets for treatment. Patients may benefit from insights that could lead to more effective therapies tailored to their specific genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with follicular lymphoma, particularly those with recurrent or treatment-resistant disease.
Not a fit: Patients with other types of lymphoma or those who do not have follicular lymphoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve treatment outcomes for patients with follicular lymphoma.
How similar studies have performed: Previous research has shown promising results in targeting genetic mutations in other types of lymphoma, suggesting potential for success in this area as well.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Malek, Sami Nimer — University of Michigan at Ann Arbor
- Study coordinator: Malek, Sami Nimer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.