Understanding how mutant STAT6 affects follicular lymphoma
Official title: The Biology of Mutant STAT6 in Follicular Lymphoma
Funded at University of Michigan at Ann Arbor · NIH-10896187 · Data updated 2026-11-12
This study is looking at how certain changes in a gene called STAT6 affect follicular lymphoma, a type of cancer, to help find better treatments that work for patients based on their unique genetic makeup.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $339,008 |
| NIH project number | 5R01CA260677-03 |
| Project ID | NIH-10896187 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with follicular lymphoma, particularly those with recurrent or treatment-resistant disease.
✕Less likely to help
Patients with other types of lymphoma or those who do not have follicular lymphoma may not benefit from this research.
What this research studies
This research investigates the role of mutant STAT6 in follicular lymphoma, a common type of non-Hodgkin's lymphoma. The team aims to identify how these mutations contribute to the disease's progression and resistance to current therapies. By analyzing genetic changes and their effects on B cell survival, the research seeks to uncover potential new targets for treatment. Patients may benefit from insights that could lead to more effective therapies tailored to their specific genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve treatment outcomes for patients with follicular lymphoma.
How similar studies have gone: Previous research has shown promising results in targeting genetic mutations in other types of lymphoma, suggesting potential for success in this area as well.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Malek, Sami Nimer — University of Michigan at Ann Arbor
- Study coordinator: Malek, Sami Nimer
Related research
Other NIH-funded projects on the same topics.
-
Preventing follicular lymphoma progression with precision therapy
This grant tests a targeted approach to stop follicular lymphoma from getting worse or turning into a more aggressive cancer.
-
Follicular Lymphoma: Better Diagnosis and Personalized Risk in B-Cell Lymphomas
This NIH grant aims to improve how doctors diagnose and predict outcomes for people with follicular lymphoma by finding reliable biomarkers to guide treatment decisions.
-
IRF4's role in shaping the tumor environment in follicular lymphoma
This grant aims to understand how a molecule called IRF4 changes the tumor surroundings in follicular lymphoma to identify potential new ways to help patients.
-
Gene test to predict early treatment failure in follicular lymphoma
A lab test that reads genes in lymphoma biopsy tissue to spot people with follicular lymphoma who are likely to have their disease return within two years after standard immunochemotherapy.
-
How mutant STAT6 affects follicular lymphoma
This project looks at how a gene change called STAT6 affects follicular lymphoma to help find better treatments for people with this cancer.
-
Preventing the progression of follicular lymphoma with targeted therapy
This study is looking at how slow-growing follicular lymphomas can change into more aggressive forms, and it's working to find personalized treatments that target the specific factors that help these tumors survive, so we can help patients live better and longer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.