Understanding how mutant KRAS causes brain blood vessel malformations
Official title: Decoding the Molecular and Cellular Mechanisms of Mutant KRAS-driven Brain Arteriovenous Malformations
Funded at University of Virginia · NIH-10991679 · Data updated 2026-11-12
This study is looking at how certain gene changes might cause brain arteriovenous malformations (bAVMs), which can lead to serious problems like strokes, and it hopes to find safer and better treatments for patients dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $577,590 |
| NIH project number | 5R01HL159159-04 |
| Project ID | NIH-10991679 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with brain arteriovenous malformations, particularly those who are children or young adults.
✕Less likely to help
Patients with bAVMs who are not candidates for pharmacological therapies or have other underlying health conditions may not benefit from this research.
What this research studies
This research investigates brain arteriovenous malformations (bAVMs), which are abnormal connections between arteries and veins that can lead to serious health issues like hemorrhagic strokes. The study focuses on the role of mutant KRAS gene mutations in the development of these malformations, using advanced techniques such as whole exome sequencing and animal models. By decoding the molecular and cellular mechanisms involved, the research aims to identify potential new treatments that could be safer and more effective than current options. Patients may benefit from insights that could lead to targeted pharmacological therapies with lower risks.
Why it matters
Potential benefit: If successful, this research could lead to safer treatment options for patients with brain arteriovenous malformations.
How similar studies have gone: Other research has shown promise in understanding genetic mutations related to vascular malformations, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Wythe, Joshua D. — University of Virginia
- Study coordinator: Wythe, Joshua D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.