Understanding how muscles use energy during movement

Collaborative Research: A Predictive Theory of Muscle Energy Consumption

['FUNDING_R01'] · WORCESTER POLYTECHNIC INSTITUTE · NIH-10493166

This study is looking at how our muscles use energy when we walk and run, and it could help create better assistive devices and prosthetics to make movement easier for people, while also giving us clues about genetic links to heart disease and muscle disorders.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorWORCESTER POLYTECHNIC INSTITUTE (nih funded)
Locations1 site (WORCESTER, UNITED STATES)
Trial IDNIH-10493166 on ClinicalTrials.gov

What this research studies

This research investigates a new theory that predicts how muscles consume energy during activities like walking and running. By developing a mathematical model based on molecular and cellular measurements, the researchers aim to understand muscle function at both small and large scales. This could lead to better designs for assistive devices and prosthetics that reduce effort for users. Additionally, the findings may provide insights into the genetic factors contributing to heart disease and other muscular disorders.

Who could benefit from this research

Good fit: Ideal candidates for this research include individuals with muscular disorders, heart disease, or those who use assistive devices for mobility.

Not a fit: Patients with stable muscle function and no history of muscular or cardiac issues may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved assistive devices and a better understanding of heart disease, enhancing patient mobility and health.

How similar studies have performed: Previous research has shown promise in developing mathematical models for muscle function, suggesting that this approach could yield valuable insights.

Where this research is happening

WORCESTER, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.