Understanding how muscles grow and stay strong
Ribosomal control of muscle mass: Transcriptional and epigenetic mechanisms
This research explores how tiny cell parts called ribosomes help muscles grow and stay healthy, especially when people experience muscle loss due to conditions like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project ID | NIH-11141045 on NIH RePORTER |
What this research studies
Our muscles are vital for our overall health, and losing muscle mass can lead to serious problems and longer recovery times. This project focuses on understanding how ribosomes, which are like tiny protein factories in our cells, control muscle growth and maintenance. We are looking at specific genetic factors that influence ribosome production and how they can lead to stronger, larger muscles. By uncovering these mechanisms, we hope to find new ways to prevent muscle loss and improve muscle function.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals experiencing muscle loss due to chronic diseases or aging.
Not a fit: Patients who do not experience muscle loss or related conditions would not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help prevent muscle wasting and improve muscle strength for patients facing conditions like cancer cachexia or aging-related muscle loss.
How similar studies have performed: While the specific genetic approach is novel, other studies have shown the importance of protein synthesis and ribosomal function in muscle health.
Where this research is happening
University Park, United States
- Pennsylvania State University, the — University Park, United States (Active)
Researchers
- Principal investigator: Nader, Gustavo a — Pennsylvania State University, the
- Study coordinator: Nader, Gustavo a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.