Understanding how muscle wasting affects cancer growth
Official title: Delineating the contribution of muscle wasting to tumor progression
Funded at Indiana University Indianapolis · NIH-10824840 · Data updated 2026-11-12
This study is looking at how losing muscle affects cancer growth and patient health, and it aims to find ways to help cancer patients who are also dealing with muscle loss.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $383,570 |
| NIH project number | 1R21AR083774-01 |
| Project ID | NIH-10824840 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients who are experiencing or at risk of muscle wasting due to their condition.
✕Less likely to help
Patients who do not have cancer or those who are not experiencing muscle wasting may not benefit from this research.
What this research studies
This research investigates the relationship between muscle wasting and tumor progression in cancer patients. It aims to understand how the loss of skeletal muscle impacts the behavior of tumors and the overall health of patients. By studying genetically engineered mice, the researchers will explore how preventing muscle wasting might influence tumor growth and patient outcomes. The goal is to develop more effective therapeutic strategies for cancer patients suffering from muscle wasting.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that enhance survival and quality of life for cancer patients experiencing muscle wasting.
How similar studies have gone: Other research has shown promising results in understanding the effects of muscle wasting on cancer progression, indicating that this approach could yield significant insights.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Doles, Jason — Indiana University Indianapolis
- Study coordinator: Doles, Jason
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.