Understanding how muscle structure affects function using advanced MRI techniques
Official title: Development and Application of Muscle Diffusion Tensor MRI
Funded at Carle Foundation · NIH-10755602 · Data updated 2026-11-12
This study is looking at how the way our muscles are built affects how well they work, and it's for anyone interested in muscle health, especially those with muscle diseases like Duchenne muscular dystrophy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Carle Foundation NIH-funded |
| Lab location | 1 site (Urbana, United States) |
| Project start | May 7, 2019 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $368,474 |
| NIH project number | 5R01AR073831-05 |
| Project ID | NIH-10755602 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with muscle disorders such as Duchenne muscular dystrophy or other related conditions.
✕Less likely to help
Patients with muscle conditions not related to the structural aspects being studied may not benefit from this research.
What this research studies
This research focuses on improving our understanding of how the structure of human muscles influences their function in both healthy individuals and those with muscle diseases. By utilizing advanced magnetic resonance imaging (MRI) techniques, specifically diffusion-tensor imaging (DTI), the researchers aim to quantify muscle architecture and its impact on muscle performance. The study will validate these imaging methods across various muscle health states, providing insights into conditions like Duchenne muscular dystrophy. The findings will be shared with the broader muscle research community to enhance knowledge and treatment approaches.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatment strategies for muscle diseases, improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using advanced MRI techniques to study muscle function, indicating that this approach could yield valuable insights.
Where this research is happening
-
Carle Foundation
Urbana, United States Active
Researchers
- Principal investigator: Damon, Bruce M. — Carle Foundation
- Study coordinator: Damon, Bruce M.
Related research
Other NIH-funded projects on the same topics.
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Carle Community Cancer Care Program (NCORP)
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.