Understanding How Muscle Stem Cells Repair Our Bodies
Cadherin-Dependent Regulation of Satellite Cell Function
This project explores how our body's muscle stem cells stay quiet or become active to repair muscle, focusing on how they communicate with their surroundings.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11124651 on NIH RePORTER |
What this research studies
Our muscles have special stem cells, called satellite cells, that help them heal after injury. Normally, these cells are resting, but when muscle gets damaged, they wake up to create new muscle. This project looks closely at how these resting cells communicate with their environment and what signals tell them to start repairing. Researchers are particularly interested in tiny projections on these cells and how certain proteins, called cadherins, control their activity. Understanding these processes is key to finding new ways to help muscles heal better.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future applications could benefit individuals experiencing muscle damage or conditions affecting muscle regeneration.
Not a fit: Patients seeking immediate clinical treatments would not directly benefit from this basic science investigation.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that improve muscle repair and regeneration for people with muscle injuries or diseases.
How similar studies have performed: While the general concept of muscle stem cells is established, the specific mechanisms of satellite cell projections and cadherin-dependent regulation are areas of active and novel exploration.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Krauss, Robert S. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Krauss, Robert S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.