Understanding how muscle stem cells develop and repair muscle
Exploring networks underlying muscle stem cell identity - Resubmission - 1
This project aims to understand how muscle stem cells get their unique identity, which is key for repairing muscle damaged by exercise, disease, or aging.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11085969 on NIH RePORTER |
What this research studies
Muscle stem cells, also known as satellite cells, are vital for repairing and rebuilding muscle tissue after injury or due to conditions like disease and aging. Scientists are working to learn how to create these important muscle-repairing cells from other types of stem cells, such as embryonic stem cells, for future regenerative medicine treatments. This project focuses on a critical factor called Pax7, which plays a major role in giving muscle stem cells their special identity. Researchers are using advanced laboratory techniques to explore how Pax7 changes the cell's genetic material to guide it toward becoming a muscle stem cell, ultimately aiming to uncover the precise steps that enable muscle stem cells to repair and regenerate muscle.
Who could benefit from this research
Good fit: This foundational work is relevant to individuals experiencing muscle damage, disease, or age-related muscle loss.
Not a fit: Patients will not receive direct, immediate benefit from this foundational laboratory research.
Why it matters
Potential benefit: If successful, this foundational work could lead to new strategies for generating muscle cells for regenerative therapies, potentially helping individuals recover from muscle damage or wasting conditions.
How similar studies have performed: While some progress has been made in understanding muscle stem cells, this approach explores novel aspects of how their identity is established.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Dynlacht, Brian D — New York University School of Medicine
- Study coordinator: Dynlacht, Brian D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.