Understanding how muscle regenerates after blood flow restriction
The 4D nucleome of muscle regeneration in ischemia-induced tissue damage and repair
This study is looking at how muscle cells heal in people with critical limb ischemia, a condition that limits blood flow and harms tissues, to find new ways to help muscles recover better, even if blood flow doesn’t improve.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10912465 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind muscle regeneration in patients suffering from critical limb ischemia (CLI), a condition caused by restricted blood flow that leads to severe tissue damage. By examining muscle stem cells and their behavior in response to ischemic damage, the study aims to uncover how the 3D structure of chromatin affects muscle repair. The researchers will analyze gene expression and chromatin organization to identify potential new treatment strategies that could enhance muscle regeneration, independent of blood flow improvements.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with critical limb ischemia who are experiencing muscle damage due to restricted blood flow.
Not a fit: Patients with muscle damage not related to ischemia or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve muscle regeneration and reduce the risk of limb amputation for patients with CLI.
How similar studies have performed: While the specific approach of analyzing 3D chromatin organization in muscle regeneration is novel, similar studies have shown promise in understanding tissue repair mechanisms.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Diao, Yarui — Duke University
- Study coordinator: Diao, Yarui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.