Understanding how muscle pain develops after blood flow issues
Mechanisms of muscle afferent sensitization after ischemia
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-10918281
This study is looking at how muscle pain and sensitivity can happen after reduced blood flow, and it wants to understand the differences between men and women in this process, so we can find better treatments for people dealing with chronic muscle pain.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10918281 on ClinicalTrials.gov |
What this research studies
This research investigates how muscle pain and sensitivity develop after episodes of reduced blood flow, known as ischemia. It focuses on the biological mechanisms that differ between males and females, aiming to uncover why some individuals experience chronic pain following these events. By studying animal models, the researchers will analyze specific gene expressions and signaling pathways that contribute to muscle pain and altered responses to exercise. The ultimate goal is to identify potential therapies for those suffering from muscle pain related to ischemia.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing muscle pain related to ischemic conditions, such as those with peripheral vascular disease or sickle cell disease.
Not a fit: Patients who do not have muscle pain or ischemic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies for muscle pain and improved cardiovascular responses in patients affected by ischemia.
How similar studies have performed: While the mechanisms of sensory transduction from the skin are well understood, this specific focus on muscle afferent sensitization after ischemia is relatively novel and has not been extensively tested.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JANKOWSKI, MICHAEL P — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: JANKOWSKI, MICHAEL P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Blood Diseases