Understanding how muscle growth affects cancer cachexia
Reverse engineering cancer cachexia: muscle ribosome biogenesis in the etiology of cachexia
['FUNDING_R15'] · OAKLAND UNIVERSITY · NIH-10796455
This study is looking at how muscle mass affects weight loss in cancer patients and whether boosting the production of ribosomes in muscle cells can help keep their muscles strong and improve their health.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OAKLAND UNIVERSITY (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10796455 on ClinicalTrials.gov |
What this research studies
This research investigates the role of skeletal muscle mass in cancer cachexia, a condition that leads to severe weight loss and poor prognosis in cancer patients. The study aims to explore how ribosome biogenesis, the process of creating ribosomes in muscle cells, influences muscle mass and its impact on survival rates among cancer patients. By using a specially designed mouse model, researchers will examine how manipulating ribosome production can help maintain muscle mass and potentially improve health outcomes for those suffering from cancer cachexia.
Who could benefit from this research
Good fit: Ideal candidates for this research are adult cancer patients who are experiencing muscle loss due to cachexia.
Not a fit: Patients who are not diagnosed with cancer or those who do not exhibit symptoms of cachexia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance muscle mass and improve survival rates in cancer patients experiencing cachexia.
How similar studies have performed: Previous research has shown promising results in enhancing muscle mass through ribosome biogenesis manipulation, indicating potential for success in this approach.
Where this research is happening
ROCHESTER, UNITED STATES
- OAKLAND UNIVERSITY — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FIGUEIREDO, VANDRE CASAGRANDE — OAKLAND UNIVERSITY
- Study coordinator: FIGUEIREDO, VANDRE CASAGRANDE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.