Understanding how muscle fibers work in health and disease
Skeletal muscle sarcomere function in health and disease
This study is looking at how tiny parts of muscle fibers work and what happens when they don’t function properly, with the goal of finding new treatments for muscle diseases like Nemaline myopathy and Distal Arthrogryposis, so that patients can have better options for managing their conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11105774 on NIH RePORTER |
What this research studies
This research investigates the function of sarcomeres, the basic units of muscle fibers, and how their dysfunction contributes to various muscle diseases. By examining the mechanisms that regulate muscle contraction, the study aims to identify potential therapeutic targets for conditions like Nemaline myopathy and Distal Arthrogryposis. The approach includes biophysical analysis and the use of biosensors to understand how muscle fibers respond to mechanical signals. Patients may benefit from insights that could lead to new treatments for muscle-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with muscle disorders such as Nemaline myopathy or Distal Arthrogryposis.
Not a fit: Patients with muscle diseases not related to sarcomere dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve muscle function and quality of life for patients with muscle diseases.
How similar studies have performed: Previous research has shown promise in targeting sarcomere dysfunction, indicating that this approach could lead to meaningful advancements in treatment.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Metzger, Joseph Mark — University of Minnesota
- Study coordinator: Metzger, Joseph Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.