NIH-funded research R01 grant

Understanding how muscle fatigue affects walking in older adults

Official title: Muscle Fatigue, Gait Alterations and Increased Energy Cost of Walking in Aging

Funded at University of Massachusetts Amherst · NIH-10867422 · Data updated 2026-11-12

This study is looking at how tired muscles affect walking and moving around in older adults, with the goal of finding ways to help them walk better and feel less fatigued.

More Fatigue research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Massachusetts Amherst
NIH-funded
Lab location1 site (Hadley, United States)
Project startSeptember 1, 2020
Project endMay 31, 2026
Funding year2024
Award (this year)$439,011
NIH project number5R01AG068102-05
Project IDNIH-10867422 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are older adults, particularly those experiencing mobility impairments or increased fatigue.

Less likely to help

Patients who are younger than 21 or do not have issues related to muscle fatigue or mobility may not benefit from this research.

What this research studies

This research investigates the impact of muscle fatigue on walking and mobility in older adults. It aims to understand how fatigue affects muscle coordination and gait mechanics, potentially leading to increased energy expenditure while walking. By measuring muscle performance and analyzing gait patterns, the study seeks to develop a framework for addressing mobility issues in aging populations. The ultimate goal is to identify effective interventions that can help improve mobility and reduce fatigue in older adults.

Why it matters

Potential benefit: If successful, this research could lead to improved strategies for enhancing mobility and reducing fatigue in older adults.

How similar studies have gone: Previous research has shown promising results in understanding muscle fatigue and its effects on mobility, indicating that this approach has potential for significant findings.

Where this research is happening

  • University of Massachusetts Amherst
    Hadley, United States
    Active

Researchers

  • Principal investigator: Boyer, Katherine Alaine — University of Massachusetts Amherst
  • Study coordinator: Boyer, Katherine Alaine

Related research

Other NIH-funded projects on the same topics.

  • Tiny brain bleeds and walking problems in older adults

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  • Understanding how aging affects brain function, walking, and thinking skills

    This study is looking at how getting older affects your brain health, walking, and thinking skills, especially for those who might be starting to have some memory or thinking challenges, to find ways to help improve your quality of life as you age.

    NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11052249

  • Investigating the link between small brain bleeds and walking problems in older adults

    This study is looking at how tiny brain bleeds might affect thinking and movement in older adults, especially those with high blood pressure, and it hopes to find ways to prevent these issues by learning more about how these bleeds happen.

    NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-10826074

  • Understanding how aging affects brain function, walking, and thinking skills

    This study looks at how getting older affects your brain health, walking, and thinking skills, especially for older adults who might be starting to have some memory issues, to find ways to help improve their quality of life and prevent falls and dementia.

    NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-10808994

  • How muscle fatigue affects walking in older adults

    This study is looking at how tired muscles affect the ability to move around in older adults, especially those over 65, to find ways to help them walk better and enjoy life more.

    NIH research University of Massachusetts Amherst · Hadley, United States · NIH-10662460

  • Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)

    A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.

    NIH research Yale University · New Haven, United States · NIH-11638490

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.