Understanding How Muscle Cells Position Their Nuclei
Mechanisms and Function of Myonuclear Positioning
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11010027
This project explores how muscle cells organize their internal parts, especially their nuclei, to help us understand and treat muscle diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11010027 on ClinicalTrials.gov |
What this research studies
Muscle fibers are large cells with many nuclei, and how these nuclei are placed is crucial for muscles to work correctly. This project aims to discover the exact ways muscle cells move and position their nuclei. Researchers are looking into how signals from tendons and nerves influence this nuclear placement. By understanding these fundamental processes, we hope to learn why muscle diseases cause nuclei to be misplaced and how to correct this.
Who could benefit from this research
Good fit: Patients with muscle diseases characterized by abnormal nuclear positioning might eventually benefit from this foundational understanding.
Not a fit: Patients with conditions unrelated to muscle function or nuclear positioning would likely not see direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to understand and treat various muscle diseases where nuclear positioning goes wrong.
How similar studies have performed: The researchers are building on their own published results, indicating prior success in related areas of muscle biology.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAYLIES, MARY K — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: BAYLIES, MARY K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.