Understanding how muscle breakdown affects blood vessel connections in dialysis patients
Interplay between skeletal muscle catabolism and remodeling of arteriovenous fistulae via YAP1/TAZ signaling
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10598499
This study is looking into why some patients on hemodialysis have problems with their arteriovenous fistulas (AVFs) not working well, and it hopes to find ways to improve how these important connections function, which could lead to better treatment options for people with chronic kidney disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10598499 on ClinicalTrials.gov |
What this research studies
This research investigates the failure of arteriovenous fistulas (AVFs), which are crucial for patients undergoing hemodialysis due to chronic kidney disease. It aims to uncover the cellular and molecular mechanisms behind AVF maturation failure, focusing on the role of muscle catabolism and specific signaling pathways. By studying the interactions between muscle breakdown and vascular health, the research seeks to identify potential therapeutic strategies to improve AVF function and longevity. Patients may benefit from insights that could lead to better treatment options for maintaining their vascular access.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with chronic kidney disease who require hemodialysis and have arteriovenous fistulas.
Not a fit: Patients who do not require hemodialysis or do not have arteriovenous fistulas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance the success rates of arteriovenous fistulas for hemodialysis patients.
How similar studies have performed: While there have been multiple clinical trials related to AVF failure, this research explores novel mechanisms that have not been extensively tested before.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHENG, JIZHONG — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: CHENG, JIZHONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.