Understanding how muscle and bone deformities develop after a birth injury to the arm
Development and Persistence of Tissue-Level Musculoskeletal Deformity Following Brachial Plexus Birth Injury
['FUNDING_R01'] · NORTH CAROLINA STATE UNIVERSITY RALEIGH · NIH-11045742
This study is looking at how a birth injury that affects the arm can cause long-term problems with muscle and bone growth, and it aims to find ways to help kids with this condition have better arm function and development as they grow.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTH CAROLINA STATE UNIVERSITY RALEIGH (nih funded) |
| Locations | 1 site (RALEIGH, UNITED STATES) |
| Trial ID | NIH-11045742 on ClinicalTrials.gov |
What this research studies
This research investigates the long-term effects of brachial plexus birth injury (BPBI), which causes muscle paralysis and can lead to deformities in the arm's bones and joints. The study aims to understand how the interactions between muscle and bone during critical growth periods contribute to these deformities. By examining the mechanical environment and its impact on bone growth, the research seeks to identify key factors that influence arm function and development in affected children. This knowledge could help inform future treatment strategies for improving outcomes in children with BPBI.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have experienced a brachial plexus birth injury.
Not a fit: Patients who do not have a brachial plexus birth injury or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options that enhance arm function and quality of life for children affected by brachial plexus birth injury.
How similar studies have performed: While the specific interactions of muscle and bone in BPBI are not well understood, similar research in other neuromuscular injuries has shown promising results in understanding tissue development and treatment outcomes.
Where this research is happening
RALEIGH, UNITED STATES
- NORTH CAROLINA STATE UNIVERSITY RALEIGH — RALEIGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAUL, KATHERINE — NORTH CAROLINA STATE UNIVERSITY RALEIGH
- Study coordinator: SAUL, KATHERINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.