Understanding how multiple drug-resistant infections spread in nursing homes
Official title: Simulating the Spread and Control of Multiple MDROs Across a Network of Different Nursing Homes
Funded at University of California-Irvine · NIH-11119007 · Data updated 2026-11-12
This study is looking at how different drug-resistant germs spread in nursing homes and how they interact with each other, so we can find the best ways to keep residents safe and healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | July 11, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $543,867 |
| NIH project number | 5U19AI172725-03 |
| Project ID | NIH-11119007 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are residents of nursing homes, particularly those at risk for infections caused by multidrug-resistant organisms.
✕Less likely to help
Patients who are not in nursing homes or those who do not have risk factors for multidrug-resistant infections may not benefit from this research.
What this research studies
This research investigates the simultaneous spread of multiple multidrug-resistant organisms (MDROs) in nursing homes, focusing on how these infections circulate and affect each other. By using advanced computational modeling, the study aims to simulate the dynamics of infection spread and evaluate various prevention strategies. The goal is to understand the combined effects of these pathogens and how interventions can be optimized to reduce infection risks across nursing homes in a specific region. This approach not only looks at individual facilities but also considers the interconnectedness of nursing homes in the community.
Why it matters
Potential benefit: If successful, this research could lead to more effective strategies for controlling infections in nursing homes, ultimately saving lives and reducing healthcare costs.
How similar studies have gone: Previous research has shown success in using computational models to understand infection dynamics, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Lee, Bruce Y — University of California-Irvine
- Study coordinator: Lee, Bruce Y
Related research
Other NIH-funded projects on the same topics.
-
Retinal cell grafts to restore sight in AMD and RP
A patient-focused program aims to replace damaged retinal cells with organized, transplant-ready sheets created from stem cells to improve vision in age-related macular degeneration and related diseases.
-
Treg-based tolerance to dystrophin immune responses in Duchenne muscular dystrophy
A new grant aims to help people with Duchenne muscular dystrophy by teaching the immune system to tolerate the dystrophin treatment delivered by gene therapy.
-
Immune and NGF factors in Alzheimer’s for adults with Down syndrome
This grant studies why people with Down syndrome develop Alzheimer’s disease by looking at immune signals and nerve growth factor problems.
-
Promoting Heart Cell Maturation with Light-Activated Engineered Peptides
Aims to help grown heart cells from stem cells mature more like real adult heart tissue using special peptide coatings that respond to light.
-
Understanding how heart nerves affect dangerous heart rhythms after a heart attack
This NIH grant studies how changes in the heart’s nerve signaling after a heart attack lead to dangerous rhythm problems, with the goal of finding ways to prevent them.
-
All of Us Southern California Consortium supports broad participation in a national health data program
A national health data program in Southern California works to recruit and retain adults to share health information and participate in research that uses this data.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.