Understanding how mucus is produced and transported in the lungs
Official title: Mucin Biosynthesis and Transport Mechanisms in Respiratory Health and Disease
Funded at University of Colorado Denver · NIH-10810773 · Data updated 2026-11-12
This study is looking at how mucus is made and moved in the lungs, especially for people with asthma, to find better ways to help clear thick mucus and improve breathing.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $109,653 |
| NIH project number | 5K99HL165072-02 |
| Project ID | NIH-10810773 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with respiratory diseases such as asthma or other conditions that involve mucus obstruction.
✕Less likely to help
Patients with respiratory conditions that do not involve mucus dysfunction may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the production and transport of mucus in the respiratory system, particularly in conditions like asthma where mucus becomes thick and difficult to clear. By studying the biology of mucins, which are key components of mucus, the research aims to uncover how these molecules are synthesized and moved within cells. The approach involves examining the cellular processes that affect mucin assembly and transport, which could lead to new therapeutic strategies for respiratory diseases. Patients may benefit from improved treatments that target mucus dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients suffering from respiratory conditions characterized by mucus dysfunction.
How similar studies have gone: Previous research has shown promise in understanding mucin biology, but this specific approach to studying mucin transport mechanisms is relatively novel.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Jaramillo Hernandez, Ana Maria — University of Colorado Denver
- Study coordinator: Jaramillo Hernandez, Ana Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.