Understanding how mucus affects infections and inflammation in the lungs
The Role of Airway Mucus in Infection and Inflammation
['FUNDING_R01'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-11092111
This study is looking at how problems with mucus clearance in cystic fibrosis can lead to ongoing lung infections, using a special rat model to learn more about it, with the hope of finding better ways to help people with CF breathe easier and stay healthier.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-11092111 on ClinicalTrials.gov |
What this research studies
This research investigates the role of abnormal mucus clearance in cystic fibrosis (CF) and its contribution to chronic lung infections. By using a new animal model, the CF rat, researchers aim to understand how mucus obstruction leads to a cycle of infection and inflammation. The study employs advanced imaging techniques to evaluate airway conditions and the effects of treatments on mucus behavior and infection clearance. This approach could provide insights into better management strategies for patients with CF.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cystic fibrosis, particularly those experiencing chronic lung infections.
Not a fit: Patients without cystic fibrosis or those with other unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic lung infections in cystic fibrosis patients.
How similar studies have performed: Previous research has shown promise in using animal models to study cystic fibrosis, indicating that this approach could yield valuable insights.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BIRKET, SUSAN ELIZABETH — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: BIRKET, SUSAN ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute infection, Airway Disease