Understanding how mucosal breaks contribute to rheumatoid arthritis
Investigating Mucosal Breaks in the Initiation and Progression of Rheumatoid Arthritis
This study is looking at how the health of your mouth might affect the start and worsening of rheumatoid arthritis, and it's for people with RA who want to help researchers understand how things like smoking and gum disease could influence their condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11083123 on NIH RePORTER |
What this research studies
This research investigates the role of oral mucosal health in the onset and progression of rheumatoid arthritis (RA), a condition that affects a significant portion of the population. By utilizing a novel method of collecting blood samples from patients at home, researchers aim to analyze immune responses over time, particularly focusing on the presence of specific bacteria and antibodies linked to RA. The study seeks to uncover how environmental factors, such as smoking and periodontal disease, may trigger immune responses that lead to RA flares. Through advanced RNA sequencing, the research aims to provide insights into the mechanisms behind RA, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with rheumatoid arthritis, particularly those with a history of periodontal disease or smoking.
Not a fit: Patients without rheumatoid arthritis or those who do not have any history of environmental risk factors related to the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of rheumatoid arthritis, potentially reducing disease flares and improving patient quality of life.
How similar studies have performed: Previous research has shown promising results in understanding the immune responses related to rheumatoid arthritis, suggesting that this approach may yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Robinson, William H — Stanford University
- Study coordinator: Robinson, William H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.