Understanding how Mtr4 and the TRAMP complex work in RNA processing
Structural and Functional Studies of Mtr4 and the TRAMP RNA Surveillance Complex
['FUNDING_R15'] · UTAH STATE UNIVERSITY · NIH-10580424
This study is exploring how certain proteins help manage RNA in our cells, which is important for keeping everything running smoothly, and it's a great opportunity for students interested in biomedical research to learn and get hands-on experience.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UTAH STATE UNIVERSITY (nih funded) |
| Locations | 1 site (LOGAN, UNITED STATES) |
| Trial ID | NIH-10580424 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the Mtr4 protein and the TRAMP RNA surveillance complex in the processing and degradation of RNA. By using biochemical, biophysical, and structural methods, the project aims to uncover how these proteins interact with RNA substrates and each other, which is crucial for maintaining cellular function. The research also involves genetic analyses to support the findings, providing a comprehensive understanding of RNA dynamics. Students interested in biomedical research will participate in this project, gaining valuable experience.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to RNA processing disorders or cancers that may benefit from advancements in understanding RNA dynamics.
Not a fit: Patients with conditions unrelated to RNA processing or those not affected by malignancies may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into RNA processing, potentially impacting treatments for various cancers and other diseases related to RNA dysfunction.
How similar studies have performed: While the specific approach of this research is novel, similar studies have shown success in understanding RNA dynamics and their implications in various diseases.
Where this research is happening
LOGAN, UNITED STATES
- UTAH STATE UNIVERSITY — LOGAN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOHNSON, SEAN J — UTAH STATE UNIVERSITY
- Study coordinator: JOHNSON, SEAN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers