Understanding how mTORC2 affects seizure control
Mechanism and role of mTORC2 in seizure reduction
This study is looking at how a protein called mTORC2 affects seizures in people with epilepsy, and it hopes to find ways to control seizures better and with fewer side effects than current medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10987009 on NIH RePORTER |
What this research studies
This research investigates the role of a protein complex called mTORC2 in the management of seizures associated with epilepsy. By using advanced techniques such as molecular genetics and phosphoproteomics, the researchers aim to uncover how mTORC2 influences seizure activity and whether inhibiting it can lead to better seizure control. The study will involve both laboratory experiments and innovative approaches to manipulate mTORC2 activity, providing insights that could lead to new treatment strategies for epilepsy. Patients may benefit from the development of more effective therapies that minimize side effects compared to current antiepileptic drugs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with epilepsy who have not achieved adequate seizure control with existing medications.
Not a fit: Patients who do not have epilepsy or those whose seizures are well-controlled with current treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce seizures with fewer adverse effects for patients with epilepsy.
How similar studies have performed: Previous research has shown promising results in targeting mTOR pathways for seizure reduction, indicating that this approach has potential for success.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Chin, Jeannie — Baylor College of Medicine
- Study coordinator: Chin, Jeannie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.