Understanding how mTOR signaling affects cell growth and survival
Mechanisms of autophagy and mTOR signaling
This study is looking at how a specific pathway in our cells helps them grow and survive, especially when they're low on energy, and it aims to understand how this pathway affects the cleanup process in cells, which could lead to new ideas for treating diseases like cancer and age-related issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10841983 on NIH RePORTER |
What this research studies
This research investigates the mTOR signaling pathway, which is crucial for regulating cell growth, survival, and metabolism based on nutrient and energy levels. The study aims to fill knowledge gaps regarding how mTOR controls the processes of autophagy, the cellular cleanup mechanism, and how cells choose between autophagy and apoptosis during energy crises. By exploring these mechanisms, the research seeks to uncover new insights into cellular responses that could impact various diseases, including cancers and age-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to cellular metabolism, such as cancer, diabetes, or age-related pathologies.
Not a fit: Patients with stable, non-progressive conditions that do not involve cellular growth or metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to cell growth and survival, such as cancer and metabolic disorders.
How similar studies have performed: Previous research has shown promising results in understanding mTOR signaling and its implications for cellular processes, indicating that this area of study has potential for significant advancements.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Kim, Do-Hyung — University of Minnesota
- Study coordinator: Kim, Do-Hyung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.