Understanding how mTOR signaling affects breast cancer growth and treatment resistance
Feedback loop and crosstalk in the mTORC1/2 signaling network
This study is looking at how certain signals in breast cancer cells affect their growth and survival, especially why some tumors don't respond to treatment, with the hope of finding better ways to fight the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10651817 on NIH RePORTER |
What this research studies
This research investigates the mTOR signaling network, which plays a crucial role in regulating cell growth and survival, particularly in breast cancer. By examining how feedback mechanisms and interactions between different signaling molecules influence cancer cell behavior, the study aims to uncover why some tumors resist treatment. The approach involves advanced techniques such as proteomics and metabolomics to analyze cellular responses to mTOR inhibition. This research could lead to improved strategies for targeting breast cancer and overcoming drug resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with malignant breast neoplasms who may benefit from new therapeutic strategies.
Not a fit: Patients with non-malignant breast conditions or those not diagnosed with breast cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for breast cancer by addressing drug resistance.
How similar studies have performed: Previous research has shown promising results in targeting mTOR signaling in cancer, indicating that this approach has potential for success.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Yoon, Sang-Oh — University of Illinois at Chicago
- Study coordinator: Yoon, Sang-Oh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.