Understanding how mTOR inhibitors work in older adults
Official title: Pharmacokinetics (PK) and Pharmacodynamics (PD) Characterization of mTOR Inhibitors in Older Adults
Funded at Ut Southwestern Medical Center · NIH-10982433 · Data updated 2026-11-12
This study is looking at how two medications, sirolimus and everolimus, might help older adults slow down the aging process, and it’s specifically for people aged 65 and older who are generally healthy.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $618,401 |
| NIH project number | 1U01AG081450-01A1 |
| Project ID | NIH-10982433 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above who are generally healthy and not suffering from severe illnesses.
✕Less likely to help
Patients who are younger than 65 or those with significant underlying health conditions may not benefit from this research.
What this research studies
This research investigates the effects of mTOR inhibitors, specifically sirolimus and everolimus, on older adults to better understand how these medications can help slow down aging processes. The study aims to gather important data on how these drugs are processed in the body (pharmacokinetics) and their effects on biological functions (pharmacodynamics) in individuals aged 65 and older. By focusing on older adults without other serious health issues, the research seeks to establish a solid foundation for future clinical trials that could lead to effective treatments for age-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for older adults, potentially slowing down the aging process and reducing the risk of chronic diseases.
How similar studies have gone: Previous research has shown promise in using mTOR inhibitors for aging-related interventions, but this specific focus on older adults without confounding illnesses is relatively novel.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Timofte, Irina — Ut Southwestern Medical Center
- Study coordinator: Timofte, Irina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.