Understanding how mTOR inhibitors work in older adults
Pharmacokinetics (PK) and Pharmacodynamics (PD) Characterization of mTOR Inhibitors in Older Adults
['FUNDING_U01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10982433
This study is looking at how two medications, sirolimus and everolimus, might help older adults slow down the aging process, and it’s specifically for people aged 65 and older who are generally healthy.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10982433 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of mTOR inhibitors, specifically sirolimus and everolimus, on older adults to better understand how these medications can help slow down aging processes. The study aims to gather important data on how these drugs are processed in the body (pharmacokinetics) and their effects on biological functions (pharmacodynamics) in individuals aged 65 and older. By focusing on older adults without other serious health issues, the research seeks to establish a solid foundation for future clinical trials that could lead to effective treatments for age-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who are generally healthy and not suffering from severe illnesses.
Not a fit: Patients who are younger than 65 or those with significant underlying health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for older adults, potentially slowing down the aging process and reducing the risk of chronic diseases.
How similar studies have performed: Previous research has shown promise in using mTOR inhibitors for aging-related interventions, but this specific focus on older adults without confounding illnesses is relatively novel.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TIMOFTE, IRINA — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: TIMOFTE, IRINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.