Understanding how mTOR Complex 2 affects insulin signaling and metabolism.
Elucidating structural, mechanistic, and allosteric determinants of mTOR Complex 2 (mTORC2) signaling.
['FUNDING_CAREER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11083654
This study is looking at how a specific protein complex helps control insulin signaling, which is important for managing blood sugar levels, and it aims to find new ways to treat diabetes and cancer by understanding how this complex works.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11083654 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which mTOR Complex 2 (mTORC2) regulates insulin signaling, particularly focusing on the phosphorylation of the Akt protein, which is crucial for glucose metabolism. The study aims to uncover the structural and allosteric factors that influence mTORC2's activity and its interactions with other proteins. By exploring these pathways, the research seeks to identify potential therapeutic targets for conditions like diabetes and cancer, where these signaling processes are often disrupted. Patients may benefit from insights that could lead to new treatment strategies for managing their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with diabetes or cancer who are affected by dysregulated insulin signaling.
Not a fit: Patients with conditions unrelated to insulin signaling or mTORC2 activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for diabetes and cancer by targeting mTORC2 signaling pathways.
How similar studies have performed: Previous research has shown promising results in targeting mTOR signaling pathways, indicating potential for success in this area as well.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAYLOR, MARTIN S — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: TAYLOR, MARTIN S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus