Understanding how MRSA bacteria survive in the bloodstream despite antibiotic treatment
Epigenomic Mechanisms & Contextual Immunity in Persistent MRSA Bacteremia
This study is looking into why MRSA, a tough bacteria that can cause infections in the blood, sometimes sticks around even when antibiotics should work, and it's aimed at helping patients by finding better ways to treat these stubborn infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center NIH-funded |
| Lab location | 1 site (Torrance, United States) |
| Project ID | NIH-11091668 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which methicillin-resistant Staphylococcus aureus (MRSA) can persist in the bloodstream of patients, even when laboratory tests show that the bacteria should be susceptible to antibiotics. The study aims to analyze the immune responses and genetic factors that allow MRSA to evade treatment, focusing on the unique characteristics of persistent infections. By examining these factors, researchers hope to identify new therapeutic strategies to combat MRSA bacteremia and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with persistent MRSA bacteremia who have not responded adequately to standard antibiotic therapies.
Not a fit: Patients with non-bacterial infections or those who do not have MRSA bacteremia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from persistent MRSA infections, potentially reducing mortality rates.
How similar studies have performed: While there have been attempts to develop vaccines and treatments for MRSA, this specific approach to understanding antibiotic persistence is novel and has not been extensively tested.
Where this research is happening
Torrance, United States
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center — Torrance, United States (Active)
Researchers
- Principal investigator: Yeaman, Michael R — Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Study coordinator: Yeaman, Michael R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.