Understanding how MRSA bacteria colonize the gut
Mechanisms of MRSA intestinal colonization
This study is looking at how a type of bacteria called CA-MRSA can settle in the stomachs of babies and young kids, using baby mice to learn more about it, so we can find better ways to keep these little ones safe from infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10756434 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) colonizes the gastrointestinal tract, particularly in infants and young children. The study uses a specialized infant mouse model to explore how factors like weaning and the presence of certain toxins influence the ability of CA-MRSA to establish itself in the gut. By understanding these processes, the research aims to identify potential strategies for controlling MRSA infections, which are a significant health risk for vulnerable populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and young children who are at higher risk for MRSA infections.
Not a fit: Patients who are adults or those without a history of MRSA colonization or infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new methods for preventing and controlling MRSA infections, particularly in infants and young children.
How similar studies have performed: Previous research has shown success in understanding bacterial colonization in animal models, but this specific approach to CA-MRSA colonization is relatively novel.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Shopsin, Bo — New York University School of Medicine
- Study coordinator: Shopsin, Bo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.