Understanding how mRNA regulation affects the nervous system
Official title: Post-transcriptional mRNA regulation in the mammalian nervous system
Funded at Yale University · NIH-11001129 · Data updated 2026-11-12
This study is looking at how changes in gene regulation can affect the nervous system and lead to diseases, especially by examining how certain genetic repeats impact the way our body makes proteins, which is important for brain health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $434,160 |
| NIH project number | 5R35GM152208-02 |
| Project ID | NIH-11001129 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological disorders that may be linked to mRNA regulation abnormalities.
✕Less likely to help
Patients with conditions unrelated to mRNA regulation or those not experiencing neurological issues may not benefit from this research.
What this research studies
This research investigates the role of post-transcriptional gene regulation in the mammalian nervous system, focusing on how its dysregulation can lead to human diseases. The team will explore the effects of microsatellite repeat expansions on mRNA processing and translation, study alternative translation initiation mechanisms, and improve methods for measuring mRNA translation efficiency. By conducting both targeted and genome-wide analyses, the research aims to uncover the underlying principles of mRNA metabolism and its implications for neurological health.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the molecular mechanisms of neurological diseases, potentially informing the development of targeted therapies.
How similar studies have gone: Previous research has shown promising results in understanding mRNA regulation in other contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Guo, Junjie — Yale University
- Study coordinator: Guo, Junjie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.