Understanding how mRNA is transported out of the cell nucleus
Official title: Structural and Functional Characterization of the S. cerevisiae mRNA export platform
Funded at Rockefeller University · NIH-11069463 · Data updated 2026-11-12
This study is looking at how a tiny structure in our cells helps move important genetic messages from the nucleus to the rest of the cell, which could help us understand how problems in this process might lead to diseases like cancer and aging-related issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AG087552-01A1 |
| Project ID | NIH-11069463 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to mRNA transport issues, such as specific cancers or age-related diseases.
✕Less likely to help
Patients with conditions unrelated to mRNA transport or those not experiencing any related health issues may not benefit from this research.
What this research studies
This research investigates the nuclear pore complex (NPC), a crucial structure that regulates the transport of mRNA from the nucleus to the cytoplasm. By examining how messenger ribonucleoprotein particles (mRNPs) are formed and exported, the study aims to uncover the mechanisms that facilitate this process. The researchers will utilize advanced techniques like cryo-electron microscopy to visualize the mRNA export platform at a high resolution, which could reveal important insights into how mutations in this pathway may lead to diseases such as cancer and age-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to mRNA transport dysfunction, including certain cancers and age-related disorders.
How similar studies have gone: Previous studies have shown promise in understanding the nuclear pore complex, but this research aims to provide novel insights that have not yet been fully explored.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Mittal, Sanraj Rao — Rockefeller University
- Study coordinator: Mittal, Sanraj Rao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.