Understanding how mRNA is recruited to the ribosome in human cells
Official title: The mechanisms of mRNA recruitment to the human ribosome
Funded at University of California at Davis · NIH-11001929 · Data updated 2026-11-12
This study is looking at how our cells pick and use messenger RNA to make proteins, which are essential for keeping our bodies working well, and it aims to help us understand how different conditions can affect this process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $362,250 |
| NIH project number | 5R35GM152137-02 |
| Project ID | NIH-11001929 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with conditions that involve altered protein synthesis, such as certain genetic disorders or cancers.
✕Less likely to help
Patients with conditions unrelated to mRNA recruitment or protein synthesis may not benefit from this research.
What this research studies
This research investigates the mechanisms by which messenger RNA (mRNA) is selected and recruited to the ribosome for protein synthesis in human cells. By utilizing advanced techniques such as real-time monitoring and fluorescence-based assays, the study aims to uncover the intricate processes that govern mRNA recruitment and the selection of initiation sites. This could lead to a better understanding of how changes in physiological conditions affect protein production, which is crucial for maintaining cellular functions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for diseases related to protein synthesis dysregulation.
How similar studies have gone: While the specific methodologies used in this research are innovative, previous studies have shown success in understanding mRNA dynamics using similar advanced techniques.
Where this research is happening
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University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Fraser, Christopher S — University of California at Davis
- Study coordinator: Fraser, Christopher S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.