Understanding how mRNA changes in the brain affect neurological functions
Regulation and biological functions of mRNA Alternative Polyadenylation in the Brain
This study is looking at how changes in a specific part of our genes might affect brain function and contribute to conditions like tuberous sclerosis, with the hope of finding new ways to help people with neurological disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10775692 on NIH RePORTER |
What this research studies
This research investigates how alternative polyadenylation (APA) of mRNA influences brain function and its potential role in neurological disorders. By using a novel technology called cTag-PAPERCLIP, the study aims to profile thousands of poly(A) sites in specific brain cell types, allowing for a deeper understanding of how these changes may contribute to conditions like tuberous sclerosis. The research focuses on identifying alterations in mRNA expression that occur when certain genes are disrupted, which could lead to new insights into brain diseases. Patients may benefit from this research as it could uncover new therapeutic targets for neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with tuberous sclerosis or other neurological disorders linked to mRNA alterations.
Not a fit: Patients with neurological conditions unrelated to mRNA alternative polyadenylation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurological disorders by identifying critical changes in mRNA that affect brain function.
How similar studies have performed: Previous research has shown promising results in understanding mRNA regulation in other contexts, suggesting potential for success in this novel approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Hwang, Hun-Way — University of Pittsburgh at Pittsburgh
- Study coordinator: Hwang, Hun-Way
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.