Understanding how MRCK proteins affect ovarian cancer growth and spread
Interrogating MRCK Protein Kinases in Ovarian Cancer
This study is looking at how certain proteins called MRCKs help ovarian cancer cells grow and spread, with the goal of finding new treatments that could stop these cells from moving around and causing more problems for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst of Fox Chase Can Ctr NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11030824 on NIH RePORTER |
What this research studies
This research investigates the role of MRCK protein kinases in the growth and metastasis of ovarian cancer cells, particularly focusing on how these proteins influence the formation of spheroids in the peritoneal cavity. By studying the mechanisms of MRCKs, the research aims to develop new therapies that inhibit these proteins, potentially blocking cancer cell migration and invasion. The approach includes examining the actin cytoskeleton and its interactions with MRCKs to understand their contribution to ovarian cancer progression. Patients may benefit from new treatment options that target these specific pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with recurrent ovarian cancer, particularly those experiencing ascites.
Not a fit: Patients with early-stage ovarian cancer or those whose cancer is not recurrent may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve outcomes for patients with recurrent ovarian cancer.
How similar studies have performed: Previous research has shown promise in targeting similar protein kinases for cancer treatment, indicating potential for success in this approach.
Where this research is happening
Philadelphia, United States
- Research Inst of Fox Chase Can Ctr — Philadelphia, United States (Active)
Researchers
- Principal investigator: Duncan, James Stuart — Research Inst of Fox Chase Can Ctr
- Study coordinator: Duncan, James Stuart
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.