Understanding how MRAP2 affects ghrelin's role in appetite regulation
Official title: Investigating the requirement of MRAP2 for ghrelin function
Funded at University of Michigan at Ann Arbor · NIH-11197927 · Data updated 2026-11-12
This study is looking at how a protein called MRAP2 works with the appetite hormone ghrelin in the brain, which could help us find new ways to manage obesity and control hunger.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | March 1, 2025 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $454,546 |
| NIH project number | 7R01DK115567-07 |
| Project ID | NIH-11197927 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with obesity or related metabolic disorders.
✕Less likely to help
Patients who are not affected by obesity or do not have metabolic disorders may not benefit from this research.
What this research studies
This research investigates the role of MRAP2, an accessory protein, in the function of ghrelin, a hormone that stimulates appetite. By studying how MRAP2 interacts with the ghrelin receptor GHSR1a in the brain, the research aims to uncover new insights into appetite regulation and obesity treatment. The approach involves examining the physiological effects of MRAP2 on ghrelin signaling in specific neurons that control food intake. This could lead to a better understanding of how to target obesity through hormonal pathways.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity by improving our understanding of appetite regulation.
How similar studies have gone: Previous research has shown promising results in understanding hormonal regulation of appetite, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Sebag, Julien Albert — University of Michigan at Ann Arbor
- Study coordinator: Sebag, Julien Albert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.