Understanding how mouse neurons organize their DNA in unique ways
Molecular basis and function of specialized nuclear structures in mouse neurons
['FUNDING_OTHER'] · RUTGERS, THE STATE UNIV OF N.J. · NIH-11086844
This study is looking at how nerve cells in mice organize their DNA in special ways to help them work better, especially in sensing smells, and it hopes to find out if this unique DNA arrangement is common in other nerve cells too.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS, THE STATE UNIV OF N.J. (nih funded) |
| Locations | 1 site (PISCATAWAY, UNITED STATES) |
| Trial ID | NIH-11086844 on ClinicalTrials.gov |
What this research studies
This research investigates how mouse neurons create specialized structures within their nuclei to organize their DNA differently than typical cells. By using advanced microscopy and genomic techniques, the team aims to uncover whether these unique nuclear architectures are common in the nervous system and how they might influence gene regulation. The study focuses on olfactory sensory neurons, which have been shown to rearrange their DNA to enhance their function related to the sense of smell. The findings could provide insights into how neurons adapt to various stimuli over time.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with neurological conditions or those interested in the genetic basis of neuronal function.
Not a fit: Patients with acute conditions unrelated to neurological function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of neuronal function and potentially inform treatments for neurological disorders.
How similar studies have performed: While the specific focus on alternative nuclear architectures in neurons is novel, similar research has shown promising results in understanding gene regulation in other cell types.
Where this research is happening
PISCATAWAY, UNITED STATES
- RUTGERS, THE STATE UNIV OF N.J. — PISCATAWAY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MONAHAN, KEVIN — RUTGERS, THE STATE UNIV OF N.J.
- Study coordinator: MONAHAN, KEVIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.